Stem cell therapy facilitates tolerance in renal transplantation
نویسندگان
چکیده
[email protected] Abbreviations ABMR: Antibody Mediated Rejections; ADMSC: Adipose Tissue Derived Mesenchymal Stem Cells; AHG: Anti-Human Globulin; ASHI: American Society of Histocompatibility and Immunogenetics; CGN: Chronic Glomerulonephritis; CNI: Calcineurin Inhibitor; CRF: Chronic Renal Failure; DMEM: Dulbecco’s Modified Eagle’s Medium; DSA: Donor Specific Antibody; DST: Donor Specific Transfusion; FCM: Flow Cross-Match; FITC: Fluorescent Isothiocynate; GVHD: Graft Versus Host Disease; HSC: Hematopoietic Stem Cells; HSCT: Hematopoietic Stem Cell Transplantation; IF/TA: Interstitial Fibrosis/ Tubular Atrophy; LA: Local Anesthesia; LCM: Lymphocyte Cross-Match; LDRT: Living Donor Renal Transplantation; MCS: Median Channel Shift; MFI: Mean Fluorescent Intensity; MLR: Mixed Lymphocyte Reaction; MSC: Mesenchymal Stem Cells; PBSC: Peripheral Blood Stem Cell; PE: Phycoerythrin; r-ATG: Rabbit Antithymoglobulin; RT: Renal Transplantation; SA: Single Antigen; SCT: Stem Cell Therapy; SCr: Serum Creatinine; TCR: T-cell Mediated Rejection; TI: Tolerance Induction; TIP: Tolerance Induction Protocol.
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Evaluation of Therapeutic Effects of Autologous Bone Marrow Mesenchymal Stem Cells to Prevent the Progression of Chronic Nephropathy in Renal Transplant
Background Chronic allograft nephropathy(CAN) is one of the most common causes of chronic and end stage renal disease. It is defined with Mainly tubular atrophy and interstitial fibrosis and no evidence of any other etiology, or functional disorder that caused at least three months after transplantation . Control of risk factors (HTN,DM,HLP, …) and limiting usage of calcineurin inhibitors...
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